BIOLOGY 2C03 Lecture Notes - Lecture 2: Sister Chromatids, Walther Flemming, Homologous Chromosome

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Meiosis in anaphase i cells go from diploid to haploid, thus explaining mendel"s principle of segregation homologues separate so alleles separate in anaphase ii 1 diploid becomes 4 haploid metaphase i explains mendel"s law of independent assortment. A collection of studies revealed that genes are on chromosomes. In fact, multiple genes are present on each chromosome. How many do we have? homologous chromosomes: a pair of matching chromosomes, one homolog from each parent. The telomere is the tip of each chromosome end. Karyotype: painting probes- fish human chromosome set: 23 chromosomes. Here we see two copies of the set (diploid) Autosomes: present in the same copy number in both males and females; number and morphology of autosomes is species-specific. Sex-chromosomes: present in different copies in males versus females female male (mammals) Review of mitosis and meiosis - connection between chromosome dynamics and mendelian principles. Development of the chromosomal theory of inheritance - connecting cytology and genetics.

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