BIOLOGY 2C03 Lecture Notes - Lecture 2: Hdac8, Smc3, Acetyl Group
13 Dec 2014
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Tutorial assignment 2: the title of the research paper is hdac8 mutations in cornelia de lange syndrome affect the cohesion acetylation cycle1 . Deardorff ma, bando m, nakato r, et al. The authors studied this subject because they wanted to understand the biological mechanism that links cdls and smc3, when an individual did not have either mutation listed above1. They found that this mechanism involved the histone deacetylase 8 (hdac8) gene, and the deacetylation of smc31. Therefore, one could potentially identify cdls affected individuals by the amount of acetylated smc3 present by the presence of the mutated. When smc3 is deacetylated, it opens up the cohesin ring structure, making the cohesin available for reassembly to be used in later cell cycles1. Cdls in some individuals is caused by a loss of function mutation in the hdac8 gene1. This is because loss of function in the hdac8 protein means that the cohesin isn"t properly.
