HTHSCI 1H06 Lecture 13: Adaptive Immunity
27 Jul 2018
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Document Summary
Innate (cid:3203) pamps are molecules that are essential for pathogen survival (cid:3203) we have one gene for trl 1, 2 etc. Broad specificity some tlr recognizes broadly all gram negative. Bcrs and tcrs recognize specific antigenic determinants. Adaptive (cid:3203) antigens can be any protein in a pathogen (cid:3203) can only recognize specific pathogens. If you don"t have innate responses (neutrophils and macrophages), the pathogen will. If you don"t have t/b cells, innate immune system can hold it off but the pathogen will take multiple until you die. Why you need both over the mouse and it will die. Memory and specificity are the hallmark features of adaptive responses. Lag exists because it takes time for dendritic cells to take the antigen to the lymph nodes to. They also gave a vaccine b, which shows a primary response, which resulted in a lag phase. Performed when antigen-presenting cells (apcs) interact with a t cell that is specific for a.
