HTHSCI 1I06 Lecture Notes - Lecture 2: Histidine Decarboxylase, Histamine Receptor, Imidazole
20 Mar 2019
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Document Summary
Important inflammatory signaling molecule, which is stored in densely packed vesicles of mast cells, found in connective tissue. Inflammation: histamine released at sites of damage triggers nearby blood vessels to dilate and become more permeable. The dilated capillaries leak fluid into neighboring tissues, causing localized swelling. Commonly used over-the-counter drugs are all basically histamine receptor antagonists (development of these drugs requires a deep understanding of how mediators function at a molecular and systemic level) Mediator: a substance released from cells as the result of the interaction of antigen with antibody or by the action of antigen with a sensitized lymphocyte. Lymphocyte: type of white blood cell involved in the production of antibodies in the humoral immune response. Antigen: a substance that enters the body and starts a process that can cause disease. Antibodies: produced by the body to fight the antigens.
