HTHSCI 2H03 Lecture Notes - Lecture 1: Central Cross-Island Highway, Ion, Drug Injection

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 2H03
• Professor: kirsten

Document Summary

Pharmacokinetics major principles: *absorption, distribution, metabolism, elimination/excretion. Routes of drug administration categories: topical, skin. Intravenous: into vein-quickest route, bypasses mambranes, nothing is lost to absorbtion: subcutaneous: under the skin. Intramuscular: into muscle: transdermal: absorbed through skin. Intrathecal: through spinal: sublingual: under the tonugue. Parenteral: c. intravenous, subcutaneous, intramuscular, intradermal, sublingual, transdermal. Intestinal p-glycoproteins (p-gp): trapped in the gut and prevent drug from being absorbed. If a drug is highly water soluble (ie: polar or ionized) then the drug can be administered iv, as it will dissolved in the blood. I(cid:374)trave(cid:374)ous drug ad(cid:373)i(cid:374)istratio(cid:374) (cid:862)skips(cid:863) the pro(cid:272)ess of a(cid:271)sorptio(cid:374: a fast onset of action can be expected. Absorption: drugs can be absorbed via two distinct processes, passive diffusion, drugs must be small in molecular size and non-polar (non-ionized, lipid soluble) to pass through biological membranes via diffusion, movement from high concentration (gut) to low concentration(bloodstream)