HTHSCI 2H03 Lecture Notes - Lecture 1: Neuromuscular-Blocking Drug, Bethanechol, Muscarinic Acetylcholine Receptor M3
24 May 2016
School
Department
Course
Professor
Document Summary
Indications (disease state) primary, secondary and tertiary. Commonly used in heathcare settings for the treatment of constipation. Stimulates smooth muscle contraction via m3 receptors coupled to gq proteins. Bethanechol is used to treat postoperative ileus and bladder atony after neuromuscular blocking agents. Does not have to do with the binding of a receptor. All people can borrow many adverse effects. Doses low doses activity of enzymes that break down ach. Inhibit acetylcholinesterase, causing an increase in ach. Affects autonomic ganglia, muscarinic, skeletal muscle and cholinergic receptors in the cns. Reversible binding, effects are reversed in 2-8 hours this is the fraction of time where the enzyme is able. Used by most farmers now this is the preferable option should it be inhaled or ingested. Salivation, lacrimation, urination, diarrhea, dyspnea, sweating, pin-prick pupils. Ganglia somatic nervous system will be affected. Can target motor neurons and somatic neurons with this drug class affect the.
