HTHSCI 3I03 Lecture Notes - Lecture 8: Antigen-Presenting Cell, Signal Peptide, Adaptive Immune System
4 Feb 2018
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Document Summary
Very little difference between this place and an antigen presenting cell. Apc displays small fragments (peptides) of what is around in the local environment; what proteins that apc has experienced, some are produced within the apc (endogenous) and some of those proteins are things that the. Apc has taken up from external local environment (exogenous: apcs survey the local environment, gobbling up stuff around them (viruses, bacteria, fungus) chop up all the proteins and display bits on surface. Mhc class 1 molecules interact with cd8 positive t cells. Naming system developed to define proteins expressed on immune cells. Cd3 t-cells: tend to respond to products of exogenous proteins. Cd8 tend to respond to products of endogenous proteins. Cd8 and cd4 are co-receptors that are required for optimal interaction of. Difference: cd8 t cell expresses a molecule on its cell surface called cd8. Cd4 + t cells & cd8 + t-cells. Typically, a t-cell will express either cd4 or cd8.
