HTHSCI 3I03 Lecture Notes - Lecture 8: B-Cell Receptor, B Cell, Antigen
12 Dec 2018
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Diversity, what for: how can we use limited number of genes to generate t cell and b cell specificity. Only difference is the spacer length (23-12: spacers will restrict the kind of components coming together. Vdj recombination: 23 and 12, you have a v and a j, in order to combine them hairpin is formed, you need enzymes rag (recombination-activating genes) which can only cut the 12, 23 length will remove the rest of the gene in-between to have v and j to come together: the rest of the gene with v, and j removed will form a new combination and be considered waste. Rag 1 and rag-2 are critical for t and b cell development: they are critical for both b cell and t cell formation. If we lock out either, we will not have mature functioning b/t cells.
