KINESIOL 1C03 Lecture 23: Kin 1C03 Lecture 23
14 Mar 2016
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Document Summary
Diabetes is a chronic metabolic disorder which adversely affects the body"s ability to manufacture and or use insulin and results in high blood glucose. Insulin is produced in the beta cells of the islets of langerhans in the pancreas and secreted in response to increased blood sugar. Insulin causes the translocation of glut4 and increases insulin uptake into cells. Daily insulin injectiong are used for management. Pancreas produces insulin, but cells become resistant (insensitivity) Pathophysiology: decreases number of insulin receptors, impaired chemical signaling for insulin, impaired transport of glut4 transporters into cell membrane, impaired glucose transporter function, impaired enzyme action. Uncontrolled diabetes can lead to kidney failure, amputations and loss of sensation, heart disease and stroke, blindness and death. Diabetic neuropathy (loss of sensation leading to amputation) Elevated risk of cvd prior to type ii diabetes diagnosis. People diabetic at baseline have the highest risk for cvd. Prior to diagnosis (pre diabetic): medium level of risk for cvd.
