LIFESCI 2A03 Lecture Notes - Lecture 1: Testability, Repeatability, Amputation
21 Oct 2015
School
Department
Course
Professor
Document Summary
What happens: muscular contraction to limit size of cut surface, thin wound epithelium forms over surface prevents infections from occurring, accumulation of undifferentiated cells called neoblasts in the blastema neoblasts migrate to cut surface; if we prevent them from doing so, regeneration will not take place since they are essential to this process, growth and differentiation of blastema a collection of undifferentiated cells is called a blastema. Takes about 40 days to form new limb: amputation, wound healing epithelial cells rapidly migrate from circumference of limb to plane of amputation 12 to 24 hours to form epidermal covering key to organization of regenerating cells and rest of process cannot happen without this, dedifferentiation cell undergoes loss of specialization and resemble embryonic cells allows for proliferation and repatterning of cells and then new limb, budding (early, medium, late) beginning of growth dedifferentiated cells accumulate at the end of stump and from blastema, which initiates growth.
