LIFESCI 3AA3 Lecture Notes - Lecture 15: Chronic Myelogenous Leukemia, Bone Marrow Examination, Sh3 Domain
9 Dec 2018
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Document Summary
Blood (hematopoietic) cells are generated from self-renewing stem cells (hscs) Hscs give rise to nonself-renewing progenitor cells that differentiate to diff blood cells, including wbcs. We will focus on myeloid stem cells / myeloblasts. Cancer of the blood that develops in bone marrow; does not form tumours. Chronic myeloid leukemia (cml): increased and unregulated growth of myeloid cells in bone marrow. Risk factors: high-dose radiation, age 65 years old, males. Chronic: no symptoms early on; often discovered during routine blood test elevated wbc counts. Acute: appears similar to flu, comes on suddenly (within days/weeks) Blood sample: less rbcs anemia, fatigue, less platelets bleeding/widespread bruising. Frequent infections, loss of appetite, weight loss, bone pain. Diagnosis: blood count (see increased granulocytes), bone marrow biopsy, genetic screening. Bcr = breakpoint cluster region protein (serine/threonine kinases activity); activates gtpases incl. Rac1 (cell growth/proliferation) and cdc42 (cell cycle progression)
