MEDRADSC 3U03 Lecture Notes - Lecture 11: Antigen, Metastasis, Endothelium
4 Jan 2017
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Not able to copy all the way down. Gem cells, telomerase to add more telomeres to the dna. Others lose the ability to control when it dies. Receptors on the outside of the cell. Continually turn on and divide all the time. Checkpoint of g1 dna has been damaged. Control points in the cell cycle completed are attached. Contrast with necrosis, when cells swell and burst, resulting in inflammatory reaction. Cancer cells are able to evade apoptosis, via mutations in the p53 gene. This is the most common defect in human cancers. Brca1 and brca2 genes produce proteins involved in the pathway that repairs dsbs by homologous recombination. Women who inherit mutations in these genes are at a high risk of breast cancer. The philadelphia chromosome is the tiny remnant of chromosome 22 that remains after exchange with chromosome 9. Angiogenesis branch out to the tumor.
