MUSIC 1A03 Lecture Notes - Lecture 6: Factor X, Thromboxane A2, Hemostasis
Document Summary
Vessels spasms, constricting the vessel and limiting blood flow to the site of injury (mitigating hemorrhage) Platelets bind with high affinity to the damaged vessel. Activating platelets release adenosine diphosphate (adp) and thromboxane a2 which stimulate the activation of the new platelets, platelets aggregation and vasoconstriction. Beginning of the healing process in hemostasis. Fibrin strands provide the scaffolding that forms the clot. Triggered when the tissue thromboplastin is released from damaged cells (outside. Triggered when collagen is exposed at the site of vascular injury to blood. Cells adjacent to the clot release tissue plasminogen activator (t-pa) which converts plasminogen into plasmin. Fibrinolysis is initiated 24-48 hours after clot formation. Medications can capitalize on the destruction of clots (for use in strokes or ischemic heart disease) iclicker: blood clots are formed through the action of which 2 processes: vasoconstriction and atherosclerosis, new platelets, platelets aggregation and vasoconstriction. Occlusion of arterial vessels leads to mi & cva.
