NURSING 2LA2 Lecture Notes - Lecture 4: Major Depressive Disorder, Serotonin Transporter, Suicidal Ideation
2 Mar 2015
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Document Summary
Including mania + depression: 10% of canadians affected, under diagnosed + undertreated. Depression: among leading causes of disability, 8% of adults, suicide = cause of death in 15 % of individuals with major depressive, 2x more common in women. Masked in men as ibs, migraines, back pain not diagnosed as depression. Bipolar disorder: 1% of population, equal among men + women. Dsm 5 criteria for depression (5 or more symptoms during 2 week period) Major depressive disorder: depressed mood, anhedonia (inability to experience pleasure, feelings of worthlessness/excessive guilt, decreased concentration, psychomotor agitation/retardation, insomnia or hypersomnia, decreased libido, change in weight or appetite, thoughts of death or suicidal ideation. Dynamic interplay amongst: (58-67%) (31-42%: genetics, environment, life history, development, biological changes. More common among 1st degree relatives (than the general population) No specific gene/genes: only found polymorphisms (variations in genes) risk. Serotonin transporter gene: most studied, contains polymorphism.
