NURSING 3PA2 Lecture Notes - Lecture 7: Myocardial Infarction, Coronary Vasospasm, Coronary Artery Disease
27 Nov 2016
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Document Summary
Endothelial cell injury: normal endothelium is smooth, with very tight junctions between individual cells, the endothelium is occasionally suspected to injury from factors such as: The endothelium loses some of its ability to produce antithrombotic and vasodilating cytokines. Foam cells release growth factors and inflammatory cytokines that worsen endothelial injury and further the process of atherogenesis. Ldl oxidation: low density lipoproteins make their way through the intact endothelium and are quickly oxidized into proinflammatory lipids, oxidized ldls serve as an attractant, causing further migration of monocytes into the subendothelium. When platelets in the blood are exposed to the subendothelium, they aggregate and adhere to the site of injury: this process is them followed by proliferation of smooth muscle. Proliferation causes the endothelial layer to pouch out, making the lumen of the vessel smaller. Myocardial ischemia is death of the tissue or myocardial infarct.
