BIOL 3053 Lecture Notes - Lecture 8: Giardia Lamblia, Helminths, Apicomplexan Life Cycle

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15 Mar 2016

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The number of serious fungai infections in humans is increasing. These are more difficult to control than bacterial inflections. Break down dead plant matter- nutrient recycling. Of over 100,000 species described, only about 200 are pathogenic to humans and animals. Molds consist of filaments of cells called hyphae. A mass of hyphae is called a mycelium. Hyphae either contain cross walls (septate hyphae) or lack cross-walls (coenocytic hyphae) Contain chitin- a strong, flexible, polysaccharide that is also found in the exoskeleton of arthropods. Molds reproduce by producing vast numbers of spores. Bacteria produce only one endospore per cell as a means of survival- are resistant to extreme heat, toxic chemicals, drying. Fungal spores are meant for reproduction- are not resistant to environmental stresses. Some fungi, notably pathogens, exhibit dimorphism- two forms of growth. Are able to adapt to environments that are hostile to bacteria. Grow better in acidic environments (e. g. ph = 5)

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Fungi Fungi are the great decomposers of the biosphere. Most plants form mycorrhizae with fungi to increase absorptive area without having to grow more roots, in this relationship fungi recieve carbohydrates from plants. Humans consume fungi, mushrooms, may use fungi as a source of drugs for blood pressure, antibiotics and immunosuppresive drugs. Fungi are used in biotechnology to produce fermetation products, and some have been very useful models to study gentics in eukaryotic cells that are unicellular such as yeasts. About one third of fungi may cause infections, mycoses, in plants, animals and humans. Fungi tolerate concentration of salt and sugar that plasmolyze bacteria in perserved foods exposed to air which contains fungal spores may germinate and may spoil food. Fungi have two body shapes, molds and yeasts. Mold are large and made of long filamentous hyphae. Hyphae form mats called mycelium ( plural is mycelia). Mycelia may extend for miles underground, making fungi the largest organism on earth. The visible portion of subterrean fungi are the fruitng bodies such as mushrooms. Yeasts are globular and unicellular. They may bud forming up 24 daughter cells from a single cell. When budding is incomplete it may produce a psuedohypa. Fungi that may exist in both body types are dimorphic fungi. In general, the yeast form of a dimorphic fungus is a pathogen, the filamentous form is not pathogenic. Examples are Histoplasmosis capsulatum (histoplasmosis) and Coccidiodes immitis (coccidioidomycosis). Fungi are saprobes, they absorb nutrients from the remains of dead plants or they lasso nematodes. Fungi may derive nutrients from a living plant utilizing haustoria which are modified hyphae that penetrate living plant tissue. Some fungi use melanin to absorb gamma rays which they convert to chemical energy. Some herbivores have fungi in thier gut microbiome to help digest plants. Zygomycota contains 1100 species and reproduces asexually through sporangiaspores, which form in a sac called a sporangium on a stalk called a sporangiaphore. An example is Nosema which is an obligate intracellular parasite in insects and honeybees. Ascomycota havd 32,000 species form haploid ascospores in sacs called ascus (asci plura) and reproduce asexually with condiospores which develop on the tips of hyphae on stalks called conidiophores. Examples are Claviceps purpurea, ergot, which grows on grain and causes abortions in cattle and hallucinations in humans. Penicillium the source of the first antibiotic discovered by Fleming in the 1940s. Saccharomyces, a facultative anaerobe, ferments sugar to produce alcohol and carbon dioxide gas and is used in baking and brewing. Neurospora was used as a model to study molecular biology, Beadle and Tatum established one gene one enzyme using this model organism.

14. Why are there more antibacterial drugs than antifungal drugs? Basidiomycota have fruiting bodies called basidiocarps. Basidiospores are dispersed by the wind and germinate in warm moist environments. An example is the pathogen Cryptococcus neoformans the leading cause of fungal meningitis

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BIOL 3053 Lecture Notes - Lecture 8: Giardia Lamblia, Helminths, Apicomplexan Life Cycle

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