NURS 2004 Lecture Notes - Lecture 8: Polyuria, Clozapine, Amitriptyline
20 Mar 2017
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Anxiety- a vague, uneasy feeling, the source of which is often nonspecific, or unknown to the individual. Insomnia- inability to sleep or remain asleep throughout the night. Sleep-wake schedule disorders- normal sleep but at the wrong time. Potentiates actions of gaba in limbic and cortical areas of brain. Not direct agonists but amplify the actions of endogenous gaba. Limits exist for amount of cns depression. Absorption- easily absorbed orally (highly lipid soluble; bbb; im/iv er situations) Metabolism- extensively metabolized (metabolites active; half life= 2-3 hrs but active metabolites is 50 hrs) Depends on patients needs: falling asleep- triazolam (halcion) (rapid onset, avoid waking- estazolam (prosom) (slower onset, anxiety- lorazepam (ativan) (intermediate duration) Exhibited by signs of drowsiness, lethargy, confusion. Gastric lavage, antidote- flumazenil (benzodiazepine receptor antagonist) Very few, but when combined with other cns depressants coma and death (i. e. alcohol, other benzos) For sleep- take at bedtime, intermittent schedule. Prepare for adverse events (i. e. ambu-bag, oxygen, etc. )
