BCHM 102 Lecture Notes - Lecture 16: Bile Acid, Familial Hypercholesterolemia, Endocytosis

• School: Queen's University
• Department: Biochemistry
• Course: BCHM 102
• Professor: Lauravan Staalduinen

Document Summary

Identify structure, synthesis and use of cholesterol and understand the regulation of cholesterol homeostasis: understand the role of the 4 different lipoproteins in transport of lipids. Cholesterol: most abundant sterol in the body. Functions: component of cell membranes (maintains fluidity embeds itself in cell membranes, precursor of bile acids, steroid hormones, and vitamin d in skin cells. Continuous supply of cholesterol is required for all cells (not all bad) comes from diet or de novo synthesis. Liver play a major role in regulating cholesterol homeostasis: medical relevance: cholesterol levels are a risk factor for atherosclerosis and coronary artery disease. Consists of: 4 ri(cid:374)gs (cid:894)(cid:862)steroid (cid:374)u(cid:272)leus(cid:863)(cid:895, hydrocarbon tail attached to the d ring at c17, hydroxyl at c3 of a ring, double bound in b ring between c5 and c6. Cholesteryl esters: cholesterol attached to a fatty acid at c-3 (hydroxyl group, more hydrophobic than cholesterol. Liver, intestine, adrenal cortex and reproductive tissues make the largest contributions to the (cid:271)od(cid:455)(cid:859)s (cid:272)holesterol.