BCHM 316 Lecture Notes - Lecture 5: Glycogen Phosphorylase, Phosphoglucomutase, Glycolysis
28 Jan 2018
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Document Summary
Amylose = unbranched chains of glucose; alpha 1-4 linkages. There are alpha 1-->6 branches every 12-14 residues. So alpha 1-->4 in the chain, then alpha 1-->6 to branch. Glycogen is highly branched, it looks like a feather. Enzymes can enter the structure and break it down energy release. At the center, there is glycogenin , a 37000 kda protein primer that has tyrosine residues to allow it to attach to sugars (at position 1) Primer: 6-8 glucose residues, end attached to glycogenin, branches from off of it. Glycogen is found in the liver ( to produce free blood glucose) an energy source for tissues other than the liver in the early phases of starvation. Glycogen is also found in muscle ; muscle glycogen stores are used solely by the muscle because the tissue lacks glucose-6-phosphatase and therefore cannot dephosphorylate g-6-p in order to make and therefore export glucose.
