MICR 221 Lecture Notes - Lecture 8: Histidine Kinase, Methyltransferase, Magnetic Ink Character Recognition
24 Apr 2018
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Mvmt twrd/away from a chem, signal detected by protein base of flagella. Aerotaxis: twrd air phototaxis: twrd light magnetotaxis: twrd magnetic field. Reorientation every 2-3 sec if no gradient present or going in the wrong direction. Attractant sugar or aa, detecter by chemors, transmemb. Mcps protiens, n exposed to outside of cell, c terminal exposed to cytoplasm inside cell. Clustered at cell poles, transmemb proteins, work to modulate chea activity and sens enviro. 5 mcps studied in e coli (tsr, tar-attracted to ni and co or aspartate and maltose, trg, tap, aer) each mcp can detect 4 diff things. C terminal is conserved and similar, n terminus is distinct so it can bind w attractant/repellant. Each monomer crosses the cm twice, ternary complex w 2 cytoplasmic che proteins (chea a histidine kinase and chew a response regulator) Ligand binds to rs periplasmic domain conformational change in cytoplasmic domain .
