MICR 221 Lecture Notes - Lecture 33: Wild Type, Grey Matter, Immunoglobulin G

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 221
• Professor: Jarrell

Document Summary

Hep c (hvc) encodes ns3-4a protease that cleaves adapter molecules req for successful signaling thru toll- like r 3 (tlr3) and the cyto prrs rig-1 and mda5. Encode type 1 ifn decoy b18r secreted from infected cells, r acts like aponge + binds type 1 ifn preventingit from binding to cellular ifn rs prevents ginaling downsteam of type 1 ifn r. Pylomavirus large t antigen binds to and inact jak1. Vaccina virus vh1 protein is a phosphatase that removes the p from act stat1. Hep c nssa protein blocks formation of isgf3 and stat dimers. Ifn act isre prod pkr (rna act kinase) which p itself in presence of dsdna then dimerizes w another pkr . P eif-2alpha so no viral protein synthesis can occur signal for cell apoptosis. Pkr: stim by ifn then act by dsrna shuts down protein syn in cell.