PHAR 100 Lecture Notes - Lecture 21: Sodium Bicarbonate, Antipyretic, Analgesic
12 Nov 2016
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Definition: drugs that can be purchased without a prescription and usually have low toxicity and self limiting symptoms. Role of government in otcd safety, efficacy and advertising. Read the label and check if the ingredients are appropriate. *inhibits cyclo-oxygenase 1 and 2 enzymes which produce prostaglandins which produce inflammation, pain and fever in nerve endings. Toxicities include gastric irritation, tinnitus, reyes syndrome in children with fever. (neurological defect) or allergies to food coloring and dyes. Also used as a blood thinner to prevent coronary risk factors in patients such as stroke, myocardial infarcts, and other cardiovascular diseases. Aspirin inhibits some of the protective mucous factors in the stomach. So they made a pill with asa and sodium bicarbonate in it. Problem -> not enough sodium bicarb to be useful. Analgesic and antipyretic like asa but not anti inflammatory. Overdoses can cause fatal hepatic necrosis (destroy liver). Counter irritants and cause local heat and vasodilation.
