PHAR 340 Lecture Notes - Lecture 5: Facilitated Diffusion, Adme, Acid Dissociation Constant
23 Dec 2018
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Adme- absorption, distribution, metabolism and excretion of drugs. Oral drug must be taken, dosage must release drug, must dissolve in gi fluids + be absorbed. Passive diff: affected by lipophilicity, ionization and conc grad of drug. Facilitated diffusion: down conc grad, availability of carriers limits this process. Active transport: against conc grad, req e, molecules that resemble endogenous sub, absorbed in si usually. Atp binding cassette (abc): 7 subfam, use atp to transfer drugs out of cell. Solute carrier (slc): 48 subfams, use atp to trans drugs into cell. Endocytosis: large molecule/drug engulfed in memb w ecf, req e. Extent and rate of active drug reaching systemic circ. Route of admin: effects peak conc and area under curve (total exposure) Iv, intramuscular + subcutaneous can be lower bc they can ppt out, subcut has slower + shallower slope than intramuscular due to less blood flow. Drug solubility, conc, sa, circ at absorp site, liver metabolism.
