PHAR 340 Lecture Notes - Lecture 9: Renal Function, Plasma Protein Binding, Cirrhosis
23 Dec 2018
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Document Summary
Age + sex w age cyp activity decreases (liver size and perfusion changes) and variability incr. Females have diff hepatic exp of enzymes (cyp3a4), less gut enzyme activity. Charbroiled food/cig smoke, low protein diet (protein needed for enzymes) and cruciferous veggies (induce phase ii enzymes) affect exp of enzymes. Prego: changes exp of drug-metab enzymes, placentra has some as well. Can confine a drug to certain space similar to plasma protein binding. Excretion routes= urine, biliary excretion (feces), exhalation, sweat, lactation. Low mw solutes (most drugs) pass fenestrated glomerulus, limit of 50-70,000 mw, only unbound drug can be filtered. 1 gfr: renal disease or incr age decrease gfr which decr drug elim. Creatinine clearance measured to make sure gfr is good, plasma creatinine level goes up as gfr goes down. 2 active secretion: in pct + dct cations + anions secreted by epithelium of pct via.
