PHAR 340 Lecture Notes - Lecture 13: Toxic Epidermal Necrolysis, Tnf Inhibitor, Interstitial Nephritis

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 340
• Professor: Thomas Massey

Document Summary

Cutaneous (skin) warning sign, minor forms are reversible, common= eczematous eruptions, photosensitivity and urticaria. Severe= stevens-johnson syndrome, toxic epidermal necrolysis (skin layer dies) ototoxicity (ear) tinnitus, hearing loss and balance disorders, may be irreversible like. Gentamicin (given to kids w ear infection) ocular: bisphosphonates for osteoporosis, antibiotics, usually reversible hematotoxicity (blood): bone marrow agranulocytosis (low wbc), anemia (low rbc), thrombocytopenia (low platelets), pancytopenia (low wbc, rbc + platelet), reversible, ex. chloramphenicol antibiotic hepatoxicity (liver): Cholestatic: hypersens prod inflame and biliary sys stops + backs up into liver. Hepatocellular: caused by toxic drug metabolite ex. Tylenol nephrotoxicity (kidney): leads to reduced drug clearance, reversible or irrev. Crystalluria: precipitation of insoluble drugs in renal tubule. Carcinogenesis some immunosuppressant therapies assoc w high risk of lymphomas, tnf ab (remicade) reports lymphoma and. Developmental toxicity other cancers in ppl taking tnf blockers. Drug exposure in week 1 (nidation stage)- removes blastocyst from endometrium, in week 2-3= baby malformation, trimester 2-3= functional disturbance (neural development)