BPK 458 Lecture Notes - Lecture 9: Cardiomyopathy, Half-Life, Fibrinogen

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The cardiovascular system and the renal system are inextricably linked. The kidney is one of the major organs involved in whole-body homeostasis which the kidney accomplishes independently but through coordination with other organs, particularly those of the cardiovascular and endocrine system. In the normal individual, the kidney receives ~ 20-25% of the cardiac output. Most of this blood flow is required to maintain the homeostatic or filtration functions of the kidney. As a result of this close relationship, the two organs must be in constant communication with each other in order to maintain optimal renal and cardiovascular hemodynamics. This is achieved through the activation of the sympathetic nervous system as well as the renin-angiotensin system. Once blood reaches the kidney, it comes in contact with the basic functional unit of the kidney which is known as the nephron. Each human kidney contains over one million nephrons. Together these nephrons are responsible for performing the filtration function of the kidney.

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