MBB 321 Lecture Notes - Lecture 18: Citric Acid, Lyase, Catabolism
15 Nov 2015
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Document Summary
The synthesis of fatty acids occur in the cytosol, however the inner mitochondrial membrane is impermeable to. Reaction mechanism (transport from mitochondrial matrix to cytosol: the enzyme citrate synthase catalyzes the condensation reaction of acetyl-coa with oxaloacetate to produce. The pyruvate is transported into the mitochondrial matrix and converted to oxaloacetate by the enzyme pyruvate. In the cytosol, the [nadph]/[nadp+] ratio is very large (high concentration of nadph) which favours a strong. Reducing environment for the reductive synthesis of fatty acids and other biomolecules. In the cytosol, the [nadh]/[nad+] ratio is much smaller (high concentration of nad+) which favours the nad+ - In the mitochondrial matrix, the [nadh]/[nad+] ratio is much larger than in the cytosol (higher concentration of. Nadh in matrix) due to the flow of electrons to nad+ from the oxidation of fatty acids, amino acids, pyruvate, and acetyl-coa, and this favours the reduction of oxygen through the electron transport chain.
