MBB 321 Lecture Notes - Lecture 21: Nonsteroidal Anti-Inflammatory Drug, Paracetamol, Ibuprofen
8 Dec 2015
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Document Summary
Eicosanoids (local hormones): paracrine hormones which act only on or near the point of hormone synthesis, Instead of being transported in the blood to act on cells in other tissues or organs. All mammalian cells produce eicosanoids, except for red blood cells. Eicosanoids function in the body"s inflammatory response, production of fever, production of pain, formation of. Blood clots, secretion of the gastric mucosa, and the regulation of blood pressure. Eicosanoids are divided into 3 major subclasses which include: prostaglandins, thromboxanes, leukotrienes. All eicosanoids are derived from arachidonic acid (20:4 5,8,11,14) which is a 20-carbon polyunsaturated fatty. Arachidonic acid functions as a precursor for the synthesis of eicosanoids, such as prostaglandins and thromboxanes. The synthesis of eicosanoids in described in the following three stages: stage 1: There are two major pathways which generate arachidonic acid from membrane phospholipids: the phospholipid (phosphatidylinositol) is cleaved by the enzyme, phospholipase a2, to. The enzyme, phospholipase a2, cleaves membrane phospholipids, which releases.
