MBB 463 Lecture Notes - Lecture 10: Ploidy, Dna Paternity Testing, Confidence Interval

• School: Simon Fraser University
• Department: Molec Biol & Biochem
• Course: MBB 463
• Professor: Sophie Sneddon

Document Summary

Autosomal chromosomes: we have 23 pairs, 22 are autosomal, undergo recombination suign meiosis, the crossover and separation. It"s the tip lmaooo: heterochromatic region, denser genetic material (coiled, euchromatic region, uncoiled genetic material. Polymorphisms in the y: 1985 first showed 2 distinct patterns feauturing mutually exclusive fragments of lengths 5. 2 and 3. 2 kb, at 5. 2 doesn"t have 3. 2, but at 3. 2 doesn"t have 5. 2. Alphoid satellites: primary sequence of human centromeres, 171 bp monomers arranged in head to tail fashion, surround higher order dna structures called alphois satellites, differences can be detected using rflp. Minimal haplotype: core set of y-str markers defines a minimal haplotype for analysis purposes, d allele, y from y chromosome, this is a nice summary of these markers. Inconclusive: ambiguous results, can"t determine one or another, failure to exclude, haplotypes are the same and could have originated from the same source.