NURS 3550H Lecture Notes - Lecture 5: Quinolone, Tendinosis, Dna Gyrase
28 Dec 2018
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Document Summary
Fluorinated analogs of nalidixic acid, a narrow-spectrum quinolone antibiotic used only for utis. Benefits derive from disrupting dna replication and cell division. Do not disrupt synthesis of proteins or the cell wall. Active against a broad spectrum of bacterial pathogens and may be administered po or iv. Inhibits two bacterial enzymes: dna gyrase and topoisomerase iv (both needed for dna replication and cell division) Respiratory tract, urinary tract, gi tract, bones, joints, skin, and soft tissues. Preferred drug for preventing anthrax in people who have inhaled anthrax spores. Because can be given orally, the drug represents an alternative to parenteral treatment for many serious infections. Not useful against infections caused by anaerobes. Variety of mild effects: gi (n/v/d, cns effects. Candida infections of pharynx and vagina may develop. In older adults, serious risk for confusion, somnolence, psychosis, visual disturbances. Cationic compounds: absorption can be reduced by compounds that contain cations.
