BIOCH200 Lecture Notes - Lecture 24: Acetyl-Coa, Transporter 2, Electrochemical Gradient
17 Apr 2018
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How to get pyruvate from cytosol to membrane: pyruvate transporter, symporter, outer-membrane of mitochondria is porous. Pyruvate to pdc: redox: pyruvate oxidized (2nd oxidation, the first one is catalyzed by gaph, one co2 produced per pyruvate, decarboxylation, irreversible/ regulated. A molecule with a thiol group: coenzyme a. Acetyl coa: has thioesters, high energy molecules, activated acetate. Acetic acid + hs-coa loses water to become ch3-c(=o)-scoa. R-c(=o)-scoa: fatty acid chain ch3-(ch2)n : add coa to activate fatty acid. Proteins can be used to make sugars but not fats. Active sites next to each other, intermediates are not pulled out. 1,3-bpg in rbc is converted in to 2,3-bpg. Calcium ion is an allosteric activator of phosphatase. Adp, pyruvate(substrate), nad+ (cosubstrate), coa (cosubstrate): inhibit kinase (stay in dephosphorylated form) Sources of electron: succinate (fadh2 for complex 2, nadh (for complex 1) 1 glucose> 2 pyruvate (2 co2)> 2 acetyl coa loses 4 co2 in cac( oxidation and decarboxylation).
