BIOL201 Lecture Notes - Lecture 24: Tumor Suppressor Gene, Cervical Cancer, P53

• School: University of Alberta
• Department: Biology (Biological Sciences)
• Course: BIOL201
• Professor: Warren Gallin

Document Summary

Both copies of a tumor suppressor gene are mutated in cancer. Tumor suppressor genes: if one is damaged the other is able to compensate and do the job. This contrast to oncogenes (they require 1 mutational event) Genetically inherited defect in rb increases the rate of tumor formation. If someone starts with 1 intact copy: probability of mutation (hereditary pre- disposition to cancer) : 1/1000. If you start with 2 intact copies: 1/1000 * 1/1000 = 1/1000 000. Hpv causes cancer by altering the activity of: rb and p53 (bcl-2, ras: pre-oncogenes) Classified into low risk and high risk categories based on frequency that a virus strain is associated with cervical cancer. Hpv-6 and hpv-11: common, most common cause of genital warts. Hpv-16 and hpv-18: account for 70% of cervical cancer events, as well as anal cancer. Not all hpv-16 and -18 infectious progress to cancer: low frequency. Gardasil vaccine protects against hpv-6, -11, -16, -18.