MICRB316 Lecture Notes - Lecture 23: Rolling Circle Replication, Antimicrobial Resistance, Plasmid
4 Apr 2016
School
Department
Course
Professor
Document Summary
Into a new host with different capabilities- survival of the plasmids- intrinsic antibiotic resistant increases the chances of survival in a host. (higher intrinsic antibiotic resistance). Some new plasmids can replicate on their own immediately after entry into new host. Transformation: dna has to be inserted into the chromosome, genes need to be inserted into a promoter, then you get adaptive advantage. For plasmids, they bring their whole machinery over. They are ready to go when they go into a new cell. Narrow host range vs. broad host range- some can transfer well, some have narrow range. A lot can replicate in both g+ and g-. Their promoters are well recognized by different kinds of bacteria. Maybe they have multiple replication gene sets that work on different bacteria- these are scary! Loops of dna found in some bacteria- ds closed circular dna. Contain special genes that are not related to basic life funcions- anibioic resistance.
