NEURO410 Lecture Notes - Lecture 2: Neurofibrillary Tangle, Amyloid Precursor Protein, Alois Alzheimer

• School: University of Alberta
• Department: Neuroscience and Mental Health Institute
• Course: NEURO410
• Professor: Dr.Kar

Document Summary

Lecture 2: normal brain, cognitive aging, mci, ad (jan 7/16) Na = normal (non-demented) brain and cognitive aging. Hba = health(cid:455) (cid:271)(cid:396)ai(cid:374) a(cid:374)d (cid:272)og(cid:374)iti(cid:448)e agi(cid:374)g (cid:894)(cid:862)supe(cid:396) (cid:271)(cid:396)ai(cid:374) agi(cid:374)g(cid:863)(cid:895) Adult cohort groups and non-demented controls: (ya = young adult; ma = middle aged; yo = young-old; mo = mid-old; oo = old-old) Ccna = canadian consortium on neurodegeneration in aging. Focus: description (what kinds of changes are occurring), explanation (why changes are occurring), potential intervention regarding changes, transitions and statuses in human lifespan. All directions: gains (growth), maintenance (stability), decline (typical), degeneration (ad, ndd) Attention to multi influences: interacting, moderators, modifiers, magnifiers, risk elevators, protection enhances. Multi forms of influence: metabolic disease, neurovascular effects, genetic risk, nutrition, brain injuries, toxins, education, fitness, social engagement, cognitive activity, pharmacological: exploring or testing specific conditions, influences, and modifiable targets of brain and cognitive aging. Observational: human cognitive, biological genetic, physical, health, neuroimaging. Epidemiological: studies of risk and protection factors, moderators.