BIOL 331 Lecture Notes - Lecture 15: Golgi Apparatus, Protein Folding, Mannose
Document Summary
Cargo gets further chemically modified and processed. In the vesicular transport model, cargo is shuttled from the cgn (cis golgi network, located closest to the rer) to the tgn (trans golgi network) in vesicles. In the cisternal maturation model, each cistern (cid:1688)matures(cid:1689) and changes in composition as it moves from the cis face to the trans face. Current model: similar to cisternal maturation model, but with vesicle retrograde (copi) transport. Retrograde system is important for golgi so that we replenish the golgi (especially the enzymes that it has to make glycosylation more effective) N-linked sugars means there is an addition of sugars to the side chain of n, if the sequence is: n x s/t, if this sequence is not found, there is no glycosylation. Highly hydrophilic, and acts like a sponge, therefore, when we take a step and pressure is exerted on the balls of our feet, water is released, and when pressure released, water is absorbed back in.