ANSC 4650 Lecture Notes - Lecture 3: Pattern Recognition Receptor, Acute-Phase Protein, Chemokine Receptor

• School: University of Guelph
• Department: Animal Science
• Course: ANSC 4650
• Professor: Niel Karrow

Document Summary

Essentials of acute inflammation: acute inflammation is triggered by sentinel cells, ex. Pathway 2 partially oxidized hmgb1: partially oxidized = disulfide bond c23 and c45, 2 cysteine oxidized, this isoform interacts with tlr4/md2 to release proinflammatory cytokines/chemokines. Pathway 3 fully oxidized hmgb1: terminally oxidized has no chemoattractant or cytokine inducing properties, does nothing. Cellular and soluble prrs: most prrs are cell assicated receptors, cell membrane, cytoplasmic, vesicle receptors, some prrs are soluble and are in bloodstream. Tlr2/6 forms a dimer and recognizes bacterial lipopeptides and. Myd88 with the help of tirap sorting protein and tir domain containing adaptor molecule 1 (trif or ticam1: with the ehlp of tram sorting proteins, adaptor proteins start. Pathway 2: the tlr4-lps complex is internalized and transported via endosomal compartment, process dpeendnet on cd14 to stabilize the tlr4-md2 complex on the plasma membrane. Other prrs: tlrs are important but many other prrs exsist, c type lectin membrane receptors, ex.