BIOM 3200 Lecture Notes - Lecture 2: Calcitriol, Parathyroid Gland, Bone Resorption

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3200
• Professor: Saleh

Document Summary

Parathyroid hormone (pth), calcitonin, vitamin d: calcitonin from thyroid gland, parathyroid hormone from parathyroid gland & 1,25- dihydroxyvitamin d3 (aka 1,25-dihydroxycholecalciferol) from kidneys are involved in ca regulation. If (cid:396)epola(cid:396)izatio(cid:374) is dela(cid:455)ed (cid:894)o(cid:396) does(cid:374)"t o(cid:272)(cid:272)u(cid:396)(cid:895), hea(cid:396)t (cid:272)a(cid:374)"t (cid:373)ai(cid:374)tai(cid:374) (cid:374)o(cid:396)(cid:373)al (cid:396)h(cid:455)th(cid:373) Unit 2: endocrinology ii: high ca levels likely have similar effects on brain by preventing normal repolarization. Summary of pth, vitamin d & calcitonin functions. Reabsorption/absorption process by which nephron (part of kidney) removes water & solutes from pre-urine & returns them to circulation blood; substances are reabsorbed from kidney into capillaries. Resorption process by which osteoclasts break down bone tissue & releases minerals, resulting in ca transfer from bone to blood. Vitamin d3 in kidneys large amts of vit d causes resorption of bone same way excess pth does: likely 1,25-dih(cid:455)d(cid:396)o(cid:454)(cid:455)(cid:272)hol(cid:272)al(cid:272)ife(cid:396)ol does this (cid:271)(cid:455) ca t(cid:396)a(cid:374)spo(cid:396)t th(cid:396)u (cid:272)ell (cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)es. Control of parathyroid hormone secretion by ca ions: i(cid:374) e(cid:454)t(cid:396)a(cid:272)ellula(cid:396) ca (cid:272)o(cid:374)(cid:272)e(cid:374)t(cid:396)atio(cid:374) sti(cid:373)ulates pa(cid:396)ath(cid:455)(cid:396)oid gla(cid:374)d to ho(cid:396)(cid:373)o(cid:374)e se(cid:272)(cid:396)etio(cid:374)