CHEM 1040 Lecture Notes - Lecture 4: Dna Replication, Okazaki Fragments, Dna Ligase
11 Oct 2018
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Document Summary
They found that the structure of the dna polymer was a two- stranded double helix. They deduced that it was made of nucleotides that consisted of a phosphate group attached to a five-carbon sugar (deoxyribose) attached to one of four nitrogenous bases. These monomers are linked to one another between the phosphate group and the sugar, which form the sugar-phosphate backbone of the molecule. Watson and crick had proposed that in order to copy itself, Dna would have to open down the center, like a zipper coming apart, so that a new dna strand could be built on top of the exposed strands. Following the rules of complimentary base pairing, adenine would pair with thymine, and cytosine would pair with guanine. This idea was called a template model, since one dna strand serves as the template for a new one. Each base has a complimentary one that it lines up with in the sequence of nucleotides.
