MBG 2040 Lecture Notes - Lecture 10: Endonuclease, Tandem Repeat, High Fidelity
19 Nov 2016
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Document Summary
The central dogma of molecular biology was first articulated by francis crick in 1958. Describes the process of how dna undergoes transcription to produce rna and rna undergoes translation to produce amino acids (polypeptide) The discovery of reverse transcriptase in retroviruses and retro-like viruses (howard. Temin and david baltimore, 1970) defined the central dogma. Dna goes to rna which goes to protein. Monozygotic twins: is evidence of accurate dna replication in action. The standards of b-form dna helix of watson and crick: Complementary base pairs (a pairs with t and g pairs with c) A and t only contain 2 hydrogen bonds (meaning it can break easier) and g and c contain 3 hydrogen bonds. Right handed double helix (right handed indicates it is in beta form): beta form is the most common form in cells of living organisms. The watson-crick double helical model is predicted by a semi-conservative mechanism (parental molecule is half conserved)
