NUTR 3210 Lecture Notes - Lecture 17: Acetyl-Coa, Beta Oxidation, Alpha And Beta Carbon

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Beta-oxidation and tca: starts with fatty acyl coa, insert a double bond between alpha and beta carbon, generate 1 fadh2 molecule. Acyl-coa dehydrogenase is the enzyme: water is added, double bond is broken and a hydroxyl group is added to bet carbon. Enzyme is enoyl coa hydrogenase: oh group is oxidized to a ketone. Enzyme is b- hydroxyacyl coa: cleavage at the beta carbon and insert coa. thiolase (acyl coa acetyltransferase) ** end result is acetyl coa, and coa activated fatty acid is 2 carbons shorter. Beta-oxidation and energy: example: palmitate (16 c fatty acid, 7 carbon cleavages (7 rounds of beta oxidation. 16/2 = 8 -1=7: 7x5 atp = 35 atp, 8 acetyl coas produced go through tca and etc, 8x12 atp = 96, total atp is 131 (2 less atp for fatty acid activation, net atp=129. **trans fats decrease the ldl receptor expression and activity.

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