NUTR 3210 Lecture Notes - Lecture 10: Heme Oxygenase, Transferrin Receptor, Ferroportin
4 Apr 2017
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Liver, meat, plant (leafy green, fruits, nuts) Only ferric (fe3+) and ferrous (fe2+) are stable in aqueous environment of body. Women higher than men because of menstruation. Even higher requirements during pregnancy for fetus. Only about 10-18% absorbed but depends on the person"s iron status. Hcl and proteases cleaves and releases mostly ferric in the stomach. The rest left to a reductase in si. Ferrous is then absorbed by divalent metal transporter 1 (dmt1) Protease in stomach and si releases heme ring from hemoglobin and myoglobin. Heme ring taken up by heme carrier protein 1 (hcp1) in si. Hydrolyzed by heme oxygenase into ferrous and protoporphyrin in enterocytes enterocyte sheds off the intestinal lining. Some iron is used or stored in ferritin in the enterocytes, but this gets lost when the. The rest of the iron get into the bloodstream via ferroportin. Chelators referred to all small organic compounds that form a complex with a metal ion.
