PATH 3610 Lecture Notes - Lecture 1: Skeletal Muscle, Metaplasia, Homeostasis

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Susan Bland

Document Summary

Cellular injury: when adaptive ability/responses of cell is exceeded, cell injury develops. In disease progress; sick / injured cells (hence malfunctioning organs) Conventional light microscope limitations; cell may appear norm, but biochemically abnormal; cell may die with no visual cues (aka rapid death) (cid:1) (cid:1) Mechanisms of cell injury & cell death: cell response to injurious stimuli depends on type of injury, duration & severity. I. e. brief, low dose of toxins = reversible cell injury. Longer ischemia of high toxins = irreversible & death: consequences of stimulus depend on type, status, adaptability & genetic makeup of injured cell. I. e. striated skeletal muscle tolerates ischemia (inadequate blood supply) longer & better than cardiac muscle; reversible with skeletal, irreversible with cardiac: cell injury results from functional & biochemical abnormalities in 1st of essential cellular components. I. e. deprivation of o2 & nutrients (hypoxia & ischemia) impairs energy-dependent functions = necrosis. Stresses affects diff. cellular organelles & biochem pathways.