PATH 3610 Lecture Notes - Lecture 5: Endothelium, Enterocyte, Necrosis

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Susan Bland

Document Summary

Resolution: ideal outcome of acute in ammation; return to normal : tissue restored to original state prior to injury. Regeneration: replacement of necrotic parenchymal cells by new parenchymal cells of the same type if tissue damage was extensive: scarring can also occur with extensive damage; either/or or combination of both. Considerably more tissue injury so true resolution cannot really occur. More parenchymal cells are lost: the functional cells of tissue/organ: i. e. myocardial cells in heart, hepatocytes in liver. Again, either regeneration or scaring or combo of two can occur. Simultaneously, necrotic cells & in ammatory debris must be removed. Regeneration: when parenchymal cells are lost, adjacent surviving cells replace them by undergoing division. Extent of regeneration depends on: ability of that cell type to divide, the numbers of surviving cells, if there"s still a surviving connective tissue framework to allow normal tissue structure.