BIOL 2410 Lecture Notes - Lecture 28: Histamine, Nitric Oxide, Intercalated Disc

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Smooth muscle cells contain myosin and actin. Actin is much more prevalent than in skeletal muscle. Myosin is much less prevalent than in skeletal muscle. Myosin is longer and coated along the entire length with myosin heads. Increases exibility of the muscle while painting high tension limits. The cytoskeleton of smooth muscle cells is unique. Connect actin to one another to make contraction uniform. Linked to the cell membrane via cytoskeletal protein. Protein of the extracellular matrix holds adjacent cells together. Distribution of force among the entire muscle unit. Anchors the cells together - also helps make a uniform force between two cells. The sarcoplasmic reticulum varies in quantity form one cell to another. Membrane invaginations called caveolae associate with the sr. Invagination - looks like its about to endocytose (an indent) - helps action potentials spread. Calcium enters from the sarcoplasmic reticulum and the extraceulluar uid initiate a contraction event in smooth muscle.

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