BIOL 2410 Lecture Notes - Lecture 29: Thyroid, Sarcomere, Signal Transduction

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Rate of depolarization in these cells determines heart rate ( beats per min) Ion permeability can be adjusted by the autonomic nervous system and the endocrine. Beginning with the sinoatrial (sa) node -> pacemaker of the heart system to modify heart rate. No resting membrane potential - then the heart would stop beating. If channels close and slow ca2+ channels open. At threshold, fast ca2+ channels open -> membrane potential increases sharply. At peak depolarization (around~20mv) ca2+ channels close and k+ channels open -> return to -60mv. If you damage your pacemaker - there are back up unites that will take place, but you wont have as high of a number of beats per minute - will make you weaker. Resting membrane potential in these cells is -90mv. Na+ channels open to depolarize the muscle cell to +20mv -> peak depolarization. Na+ channels close and fast k+ channels open. Slow, voltage gated ca2+ channels open and fast k+ channels close.

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