BIOL 2420 Lecture Notes - Lecture 26: Cholecystokinin, Amylase, Gastric Inhibitory Polypeptide

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 2420
• Professor: W.G.Anderson

Document Summary

Questions: de ne alkaline tide (high ph in blood stream) In parietal cells with histamine bound to the receptor - activates adenylate cyclase. Actively shuf ing out the proton to the lumen. Exchanging bicarbonate to the other side which brings in cl- to the lumen, making hcl. Regulation of gastric secretions: aa (+ vagus nerve) stimulate gastrin secretion (g-cells, gastrin (+ vagus nerve) stimulates secretion of histamine (ecl cells, histamine stimulates hcl secretion by parietal cells. 4. low ph inhibits release of gastrin (likely mediated by somatostatin (d-cells)) Triggered by acidic chyme entering the duodenum. Triggered by lipids in the duodenum and jejunum. The hormone secretin is released to inhibit parietal and chief cell secretion * Gastric inhibitory peptide: strong inhibition of gastric secretions. Exocrine pancreas is extremely important in digestions. Products collectively called pancreatic juice (~ 1500 ml/ day) Increases the luminal ph ~3 to ~7. Bicarbonate produced by the enzyme carbonic anhydrase (ca)