BIOL355 Lecture Notes - Lecture 18: Programmed Cell Death, Master Clock, Senescence
21 Apr 2017
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Document Summary
Found that p53 is upregulated in senescent cells. These cells are held up in g1/s border. They enter g0 which results in replicative senescence and usually apoptosis. Function: to control production of hormones by the pituitary gland. Info carried from hypothalamus through body by neurons/hormones. As you get older, signals get weaker (decrease in hormones, decrease in number of neurons, decrease in receptors on cells, decrease on neurotransmitters. Output or function of target organs that depend on hypothalamus and pituitary will suffer: changes typical of aging may result. Could support notion that aging is extrinsic to the cell in vivo. Certain factors that regulate gene expression (hormones/neurons) become limiting with age (hypothalamus?) As factors change, genes are turned on or off in response. Factors limiting with age: what we know for sure: gene expression decrease with age, decrease hormones, neurotransmitter and neurons, decrease functional capacity with age. White blood cells involved in final stage of apoptosis.
