BIOL373 Lecture Notes - Lecture 17: Macula Densa, Juxtaglomerular Apparatus, Angiotensin
2 Sep 2019
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What stimulates aldosterone secretion: primary action of aldosterone is na+ reabsorption (and k+ secretion, two primary stimuli for aldosterone release, plasma [k+] monitored by cells in the adrenal cortex aldosterone protects against. Hyperkalemia": blood pressure involves a complex pathway. Involved in salt and water balance: macula densa cells release paracrine factors that act on smooth muscle of afferent arteriole. Ras and hypertension: blocking angiotensin ii if of great interest for treatment of hypertension, ace inhibitors, angiotensin receptor blockers (antagonists, fewer side effects than ace inhibitors, direct renin inhibitors (recently approved) What mechanisms oppose avp and aldosterone: avp and aldosterone promote conservation of water and na+, resp, contribute to keeping blood pressure/ volume up. Is there a hormone that promotes loss of water and na+? (diuresis and natriuresis, resp: researchers (@ queens) interested in storage granules in myocardial cells, 1980 discovered that treating rate with ground-up atria caused rapid, transient excretion of.
