BIOL 200 Lecture Notes - Lecture 4: Vesicle Fusion, Copii, Clathrin
Document Summary
You can have integral cargo protein too (also needs . Cargo receptor link cargo protein molecule to to form vesicle. Expect primary cargo to be proteins that are to break down other proteins (proteases) Does not have a specific adapter protein like copii and clathrin. Coat proteins & adaptor proteins bind to cargo receptors. Primary cargo: something that will be secreted, intermembrane proteins (plasma membrane proteins, receptors), anything that leaves the er (will leave through this pathway) All of them will have different rab proteins. Lock and key model have vesicle that have components that bind to specific receptor membrane. Need right combinations of snares (lock and key model) for vesicle fusion. Helical winding of one another increases the likelihood of fusion. What happens in the cytosol stays in the cytosol!! Mammalian cell golgi are more localized around the nucleus; flattened stacks. Insertion of protein into er lumen & adds sugar tree group (mannose.
