PCTH 201 Lecture Notes - Lecture 7: Angiotensin Ii Receptor Blocker, Ace Inhibitor, Angiotensin-Converting Enzyme

• School: UBC
• Department: Pharmacology and Therapeutics
• Course: PCTH 201
• Professor: Andrew Horne

Document Summary

Antihypertensive agents: drugs for reducing bp in hypertension: diuretics (thiazide): renal na+ excretion ( bv co), dilate arterioles ( tpr, angiotensin converting enzyme inhibitor (captopril): angiotensin ii ( tpr) *angiotensin a vasoconstrictor: angiotensin receptor antagonist (losartan): block angiotensin ii receptor ( tpr, -adrenoceptor antagonist (propranolol, metoprolol; -blocker): cardiac stimulation. They also sympathetic nerve activity ( co, tpr: -adrenoceptor antagonist (prazosin, 1- blocker): vasoconstriction ( tpr) In the kidney, blood plasma is filtered via a semi- permeable membrane into the renal tubules: during passage through the renal tubules, most the na+ and water are reabsorbed into the tubular cells and the blood. Diuretics (e. g. chlorothiazide) decrease bp by: renal na+ reabsorption urine flow but bv co, dilation of arterioles ( tpr) Note: blood pressure (bp), cardiac output (co), total peripheral resistance (tpr), blood volume (bv) Inhibits the activity of angiotensin converting enzyme (ace) Synthesis of angiotensin ii ( tpr bp) and. Synthesis of aldosterone ( blood volume co and bp)